The Giant Waxy Tree Frog has a slim body with a rounded snout. It has slender legs with toes and fingers having small adhesive discs for climbing when necessary. They have four toes per foot, each with a wide, flattened tip and a suction cup pad to help grip.
The frog is less than two inches long and has no teeth. Its color, bright blue with black dots on its back and a light stomach, alerts potential predators that its skin holds a poisonous liquid which is unpleasant to the taste. The alkaloid poisons are capable of paralyzing and even killing predators. Males and females appear quite similar.